Resistance to cardiac doxorubicin damage in a Gsta4 knockout mouse
نویسندگان
چکیده
منابع مشابه
cardiac damage in left breast cancer patients
Introduction :Today there is general awareness of the potential damage to the heart in left- sided (more than in rightsided) breast cancer radiotherapy. Material & Method: Historical changes in tumor and heart doses are presented here along with the impact of different RT techniques and volumes. Results: Individual and pharm...
متن کاملDoxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance
With the extensive application of doxorubicin (DOX), DOX resistance has become one of the main obstacles to the effective treatment of breast cancer. In this paper, DOX and resveratrol (RES) were co-encapsulated in a modified PLGA nanoparticle (NPS) to overcome the DOX resistance. CLSM results indicated that DOX and RES were simultaneously delivered into the nucleus of DOX-resistant human breas...
متن کاملModulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice.
BACKGROUND Toll-like receptors (TLRs) are members of the interleukin-1 receptor family and are involved in the responsiveness to pathogen-associated molecular patterns. Recent studies have demonstrated that TLRs are activated by endogenous signals, such as heat shock proteins and oxidative stress, which may contribute to congestive heart failure. Oxidative stress is one of the major factors in ...
متن کاملBcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation.
OBJECTIVE We recently reported that doxorubicin (Dox), an effective anti-cancer drug, induces apoptosis in cardiac myocytes in association with reduction of Bcl-xl expression. In the present study, we further examined whether overexpression of Bcl-xl ameliorates Dox-induced cardiac myocyte damage. METHODS AND RESULTS Overexpression of the Bcl-xl gene by adenovirus vector resulted in an 11-fol...
متن کاملNew mouse is a knockout.
The potential of cis-diamminedichloroplatinum(II) (CDDP), trans-di(2-nitroimidazole)dichloro-platinum(II) (NIPt),
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.712.1